Vitamin E Derivative Alpha-Tocotrienol Failed to Show Neuroprotective Effects after Embolic Stroke in Rats

نویسندگان

  • Aliasghar Pourshanazari Department of Physiology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
  • Behnam Heshmatian Department of Physiology, School of Medicine, West Azarbaeejan University of Medical Sciences, Oroomiah, Iran
  • Mohammad Allahtavakoli Department of Physiology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
چکیده مقاله:

Objective(s) Previous studies have demonstrated that pretreatment with alpha-tocotrienol (a-TCT) can reduce ischemic damage in mice following middle cerebral artery (MCA) occlusion. It is also reported to decrease stroke- dependent brain tissue damage in 12-Lox-deficient mice and spontaneously hypertensive rats. In the present study, the neuroprotective effects of a-TCT and rosiglitazone (RGZ) at 3 hr after cerebral ischemia were investigated. Materials and Methods Stroke was induced by embolizing a preformed clot into the MCA. Rats were assigned to vehicle, a-TCT (1 or 10 mg/kg), RGZ and sham-operation. Results Compared to the control group, only RGZ decreased infarct volume (P

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vitamin e derivative alpha-tocotrienol failed to show neuroprotective effects after embolic stroke in rats

objective(s) previous studies have demonstrated that pretreatment with alpha-tocotrienol (a-tct) can reduce ischemic damage in mice following middle cerebral artery (mca) occlusion. it is also reported to decrease stroke- dependent brain tissue damage in 12-lox-deficient mice and spontaneously hypertensive rats. in the present study, the neuroprotective effects of a-tct and rosiglitazone (rgz) ...

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عنوان ژورنال

دوره 12  شماره 1

صفحات  9- 17

تاریخ انتشار 2009-01-01

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